Article
Use of community genetic screening to prevent HFE-associated hereditary haemochromatosis.
Lancet (London, England) - 1 Jan 2000
Delatycki M B, Allen K J, Nisselle A E, Collins V, Metcalfe S, du Sart D, Halliday J, Aitken M A, Macciocca I, Hill V, Wakefield A, Ritchie A, Gason A A, Nicoll A J, Powell L W, Williamson R
Abstract excerpt
HFE-associated hereditary haemochromatosis is a recessive, iron-overload disorder that affects about one in 200 north Europeans and that can be easily prevented. However, genetic screening for this disease is controversial, and so we assessed whether such screening was suitable for communities. Cheek-brush screening for the Cys282Tyr HFE mutation was offered to individuals in the workplace. Outcomes were assessed...
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