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Article

Exonization of AluYa5 in the human ACE gene requires mutations in both 3' and 5' splice sites and is facilitated by a conserved splicing enhancer.

Nucleic acids research - 1 Jan 2005

Lei Haixin, Day Ian N M, Vorechovský Igor

Abstract excerpt

Ancient Alu elements have been shown to be included in mature transcripts by point mutations that improve their 5' or 3' splice sites. We have examined requirements for exonization of a younger, disease-associated AluYa5 in intron 16 of the human ACE gene. A single G>C transversion in position -3 of the new Alu exon was insufficient for Alu exonization and a significant inclusion in mRNA was only observed when...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Peptidyl-Dipeptidase A

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Source

Open in PubMed Open full text

Identifiers

PMID: 16027113
DOI: 10.1093/nar/gki707
PMCID: PMC1175817

Genes

ACE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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