Article
Comparative genomics of trypanosomatid parasitic protozoa.
Science (New York, N.Y.) - 15 Jul 2005
El-Sayed Najib M, Myler Peter J, Blandin Gaëlle, Berriman Matthew, Crabtree Jonathan, Aggarwal Gautam, Caler Elisabet, Renauld Hubert, Worthey Elizabeth A, Hertz-Fowler Christiane, Ghedin Elodie, Peacock Christopher, Bartholomeu Daniella C, Haas Brian J, Tran Anh-Nhi, Wortman Jennifer R, Alsmark U Cecilia M, Angiuoli Samuel, Anupama Atashi, Badger Jonathan, Bringaud Frederic, Cadag Eithon, Carlton Jane M, Cerqueira Gustavo C, Creasy Todd, Delcher Arthur L, Djikeng Appolinaire, Embley T Martin, Hauser Christopher, Ivens Alasdair C, Kummerfeld Sarah K, Pereira-Leal Jose B, Nilsson Daniel, Peterson Jeremy, Salzberg Steven L, Shallom Joshua, Silva Joana C, Sundaram Jaideep, Westenberger Scott, White Owen, Melville Sara E, Donelson John E, Andersson Björn, Stuart Kenneth D, Hall Neil
Abstract excerpt
A comparison of gene content and genome architecture of Trypanosoma brucei, Trypanosoma cruzi, and Leishmania major, three related pathogens with different life cycles and disease pathology, revealed a conserved core proteome of about 6200 genes in large syntenic polycistronic gene clusters. Many species-specific genes, especially large surface antigen families, occur at nonsyntenic chromosome-internal and...
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