Article
Secretoglobin 2A1 is under selective androgen control mediated by a peculiar binding site for Sp family transcription factors.
Molecular endocrinology (Baltimore, Md.) - 1 Dec 2005
Xiao Fei, Mirwald Andreas, Papaioannou Maria, Baniahmad Aria, Klug Jörg
Abstract excerpt
Human secretoglobin (SCGB) 2A1 (or lipophilin C, lacryglobin, mammaglobin B) is a small protein of unknown function that forms heterodimers with secretoglobin 1D1 (lipophilin A) in tears and is expressed in the prostate. Here we show that SCGB 2A1 is under androgen control in the androgen-responsive prostatic cell line LNCaP and can be induced more than 20-fold by dihydrotestosterone. Only 6 h after androgen...
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