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Article

Possible role of adaptive mutation in resistance to antiandrogen in prostate cancer cells.

The Prostate - 1 Nov 2005

Hara Takahito, Kouno Jin, Nakamura Kazuyo, Kusaka Masami, Yamaoka Masuo

Abstract excerpt

BACKGROUND: Some mutations of androgen receptor (AR) confer resistance to antiandrogen to prostate cancer (PC) cells. Previously we reported that LNCaP-cxD2 cells established from androgen-dependent LNCaP-FGC PC cells as an antiandrogen bicalutamide-resistant subline harbor W741C/L mutation in the AR gene. In this report, we examined one possible mechanism of the resistance. METHODS: Change in the gene expression...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16015592
DOI: 10.1002/pros.20282

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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