Article
Dynamics of intrapulmonary bacterial growth in a murine model of repeated microaspiration.
American journal of respiratory cell and molecular biology - 1 Nov 2005
Ben-David Itzhak, Price Sarah E, Bortz David M, Greineder Colin F, Cohen Samuel E, Bauer Amy L, Jackson Trachette L, Younger John G
Abstract excerpt
To study the change in intrapulmonary bacterial growth rate over time during Gram-negative pneumonia, a two-hit model of recurrent bacterial aspiration was developed in mice. A mutant of Klebsiella pneumoniae was isolated that could be distinguished from the wild type when cultured on appropriate media. These strains were intranasally administered, 4 h apart, to mice whose lungs were quantitatively cultured 24 h...
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