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Article

Different splicing defects lead to differential effects downstream of the lipid and protein phosphatase activities of PTEN.

Human molecular genetics - 15 Aug 2005

Agrawal Shipra, Pilarski Robert, Eng Charis

Abstract excerpt

PTEN, encoding a dual phosphatase tumor suppressor, is mutated in 85 and 65% of individuals with Cowden syndrome (CS) and Bannayan-Riley-Ruvalcaba syndrome (BRRS), respectively. Approximately 23 germline mutations in putative splice sites have been published, but resulting downstream outcome data...

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Source

Identifiers

PMID: 16014636
DOI: 10.1093/hmg/ddi246

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16014636-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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