Article
Ammodytoxin, a secretory phospholipase A2, inhibits G2 cell-cycle arrest in the yeast Saccharomyces cerevisiae.
The Biochemical journal - 15 Oct 2005
Petrovic Uros, Sribar Jernej, Matis Maja, Anderluh Gregor, Peter-Katalinić Jasna, Krizaj Igor, Gubensek Franc
Abstract excerpt
Ammodytoxin (Atx), an sPLA2 (secretory phospholipase A2), binds to g and e isoforms of porcine 14-3-3 proteins in vitro. 14-3-3 proteins are evolutionarily conserved eukaryotic regulatory proteins involved in a variety of biological processes, including cell-cycle regulation. We have now shown that Atx binds to yeast 14-3-3 proteins with an affinity similar to that for the mammalian isoforms. Thus yeast...
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