Article
An increase in telomere sister chromatid exchange in murine embryonic stem cells possessing critically shortened telomeres
6 Jul 2005
Abstract excerpt
Telomerase deficiency leads to a progressive loss of telomeric DNA that eventually triggers cell apoptosis in human primary cells during prolonged growth in culture. Rare survivors can maintain telomere length through either activation of telomerase or recombination-based telomere lengthening, and thus proliferate indefinitely. We have explored the possibility that telomeres may be maintained through telomere...
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