Article
Progress towards understanding the genetic pathogenesis of systemic lupus erythematosus.
Novartis Foundation symposium - 1 Jan 2005
Behrens Timothy W, Graham Robert R, Kyogoku Chieko, Baechler Emily C, Ramos Paula S, Gillett Clarence, Bauer Jason, Ortmann Ward A, Hippen Keli L, Peterson Erik, Langefeld Carl D, Moser Kathy L, Gaffney Patrick M, Gregersen Peter K
Abstract excerpt
In order to better understand the genetic factors that initiate systemic lupus erythematosus (SLE), we are using both linkage and association approaches to identify susceptibility genes for the disease. Association studies have recently identified three HLA Class II haplotypes as well as a functional missense polymorphism in protein tyrosine phosphatase (PTP) PTPN22 as important risk alleles for SLE. Here, we...
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