Surface‐binding autoantibodies to cerebellar neurons in opsoclonus syndrome

Abstract excerpt

Childhood opsoclonus-myoclonus syndrome can occur with or without associated neuroblastoma. An autoimmune pathogenesis has been discussed for both forms. We show here that the majority of children with opsoclonus-myoclonus syndrome (10/14) have autoantibodies binding to the surface of isolated rat cerebellar granular neurons. In some patients, these antibodies are masked by IgG binding to ubiquitous surface...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Autoimmune Neurological Disorders and Treatments
• Share to Cellular transport and secretion
• Share to Glycogen Storage Diseases and Myoclonus