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Article

Obese subjects carrying the 11482G>A polymorphism at the perilipin locus are resistant to weight loss after dietary energy restriction.

The Journal of clinical endocrinology and metabolism - 1 Sept 2005

Corella Dolores, Qi Lu, Sorlí José V, Godoy Diego, Portolés Olga, Coltell Oscar, Greenberg Andrew S, Ordovas José M

Abstract excerpt

CONTEXT: Dietary treatment of obesity could be improved if predictive information about the individual's genetic response to diet was available. Adipose tissue has been the focus of efforts to identify candidate genes. Perilipin is a major protein found in adipocytes, and perilipin knockout mice are lean and resistant to diet-induced obesity. OBJECTIVE: The objective of the study was to examine the association of...

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Identifiers

PMID: 15985482
DOI: 10.1210/jc.2005-0576

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Obese subjects carrying the 11482G>A polymorphism at the perilipin locus are resistant to weight loss after dietary energy restriction.PMID 15985482Read ↗

Relationship between perilipin gene polymorphisms and body weight and body composition during weight loss and weight maintenance.Semantic proximity Read ↗

Effects of perilipin (PLIN) gene variation on metabolic syndrome risk and weight loss in obese children and adolescents.Semantic proximity Read ↗

Genetic variation at the perilipin locus is associated with changes in serum free fatty acids and abdominal fat following mild weight loss.Semantic proximity Read ↗

Genetic variation at the perilipin (PLIN) locus is associated with obesity-related phenotypes in White women.Semantic proximity Read ↗

Lunch eating predicts weight-loss effectiveness in carriers of the common allele at PERILIPIN1: the ONTIME (Obesity, Nutrigenetics, Timing, Mediterranean) study.Semantic proximity Read ↗

Preliminary findings on the role of PLIN1 polymorphisms on body composition and energy metabolism response to energy restriction in obese women.Semantic proximity Read ↗

Polymorphism PLIN1 11482 G>A interacts with dietary intake to modulate anthropometric measures and lipid profile in adults with normal-weight obesity syndrome.Semantic proximity Read ↗

RS2289487 variation in PERILIPIN gene is a predictor of weight loss and protection against impaired glucose metabolism after a meal-replacement diet in postmenopausal obese females.Semantic proximity Read ↗

The 11482G >A polymorphism in the perilipin gene is associated with weight gain with rosiglitazone treatment in type 2 diabetes.Semantic proximity Read ↗

Gender-specific association of a perilipin gene haplotype with obesity risk in a white population.Semantic proximity Read ↗

Genetic Polymorphisms and Weight Loss in Obesity: A Randomised Trial of Hypo-Energetic High- versus Low-Fat DietsSemantic proximity Read ↗

Genetic Predictors of ≥5% Weight Loss by Multidisciplinary Advice to Severely Obese Subjects.Semantic proximity Read ↗

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