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Article

Evaluation of a new line probe assay for rapid identification of gyrA mutations in Mycobacterium tuberculosis.

Antimicrobial agents and chemotherapy - 1 Jul 2005

Giannoni Federico, Iona Elisabetta, Sementilli Federica, Brunori Lara, Pardini Manuela, Migliori Giovanni Battista, Orefici Graziella, Fattorini Lanfranco

Abstract excerpt

Resistance of Mycobacterium tuberculosis to fluoroquinolones (FQ) results mostly from mutations in the gyrA gene. We developed a reverse hybridization-based line probe assay in which oligonucleotide probes carrying the wild-type gyrA sequence, a serine-to-threonine (S95T) polymorphism, and gyrA m...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15980370
DOI: 10.1128/AAC.49.7.2928-2933.2005
PMCID: PMC1168684

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15980370-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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