Article
Use of micro-rotation imaging to study JNK-mediated cell survival in Theileria parva-infected B-lymphocytes.
Parasitology - 1 Jun 2005
Lizundia R, Sengmanivong L, Guergnon J, Müller T, Schnelle T, Langsley G, Shorte S L
Abstract excerpt
Lymphocytes infected with the protozoan parasite Theileria parva are transformed to permanently proliferating cells, an event underlying the pathology of the disease. However, the molecular signalling mediating this process is complex and poorly understood. Here, we show that down-regulation of JNK signalling by transient over expression of a dominant-negative mutant of JNK (JNK-APF) significantly increases...
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