Article
Intestinal bacteria and development of the B-lymphocyte repertoire.
Trends in immunology - 1 Aug 2005
Lanning Dennis K, Rhee Ki-Jong, Knight Katherine L
Abstract excerpt
Vertebrates have a large antibody repertoire with diverse antigen specificities, poised to react to invading pathogens, such as bacteria, viruses and helminths. In some species, microbes such as these are required for development of both diverse antibody and B-lymphocyte repertoires. Recent studies demonstrate that B-lymphocyte expansion, selection and somatic diversification of Ig genes are regulated in these...
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