Article
[Significance of -191G/C single nucleotide polymorphisms in the promoter region of ATP-binding cassette transporter gene in coronary artery disease].
Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA - 1 Jun 2005
Liu Ling, Guo Zhi-gang, Wang Qi-guang, Liu Sheng-lin, Lai Wen-yan, Tu Yan
Abstract excerpt
OBJECTIVE: To investigate the effect of -191G/C single nucleotide polymorphisms (SNP) in the promoter region of ATP-binding cassette transporter A1(ABCA1) gene on plasma lipids and its significance in coronary artery disease (CAD). METHODS: By polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), -191G/C SNP in the promoter region of ABCA1 gene was analyzed in 204 patients with CAD and...
Topics
- ATP Binding Cassette Transporter 1
- ATP-Binding Cassette Transporters
- Aged
- Aged, 80 and over
- Cholesterol
- Coronary Artery Disease
- Female
- Genotype
- Humans
- Lipoproteins, HDL
- Male
- Middle Aged
- Polymorphism, Single Nucleotide