Article
A comparison of the phenotype and genotype in adenomatous polyposis patients with and without a family history.
Familial cancer - 1 Jan 2005
Truta Brindusa, Allen Brian A, Conrad Peggy G, Weinberg Vivian, Miller Glenn A, Pomponio Rob, Lipton Lara R, Guerra Germano, Tomlinson Ian P M, Sleisenger Marvin H, Kim Young S, Terdiman Jonathan P
Abstract excerpt
OBJECTIVES: Adenomatous polyposis of the colon is often secondary to an inherited mutation in adenomatous polyposis coli (APC) gene, however, approximately one third of patients have no family history of the disease. We studied the phenotype and genotype of adenomatous polyposis in patients without a family history. METHODS: A cohort of 57 unrelated adenomatous polyposis patients were evaluated. Seventeen...
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