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Article

A beneficial effect of simvastatin on DNA damage in 242T allele of the NADPH oxidase p22phox in hypercholesterolemic patients.

Clinica chimica acta; international journal of clinical chemistry - 1 Oct 2005

Shin Min-Jeong, Cho Eun Young, Jang Yangsoo, Lee Jong Ho, Shim Won-Heum, Cho Seung-Yun, Rim Se-Joong, Kang Seok-Min, Ha Jong-Won, Ko Young-Guk, Kim Sung-Soon, Park Hyun Young, Chung Namsik

Abstract excerpt

BACKGROUND: The effect of simvastatin on DNA damage in hypercholesterolemic patients was investigated, and the relationship between the C242T polymorphism of the NADPH oxidase p22phox gene and the antioxidant effects of simvastatin was examined. METHODS: Simvastatin (20-40 mg /day) was administered for 8 weeks in 72 hypercholesterolemic patients. DNA damage in lymphocytes was quantified using single-cell gel...

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PMID: 15936011
DOI: 10.1016/j.cccn.2005.04.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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