Article
The HtrA protease of Campylobacter jejuni is required for heat and oxygen tolerance and for optimal interaction with human epithelial cells.
Applied and environmental microbiology - 1 Jun 2005
Brøndsted Lone, Andersen Marianne Thorup, Parker Mary, Jørgensen Kirsten, Ingmer Hanne
Abstract excerpt
Campylobacter jejuni is a predominant cause of food-borne bacterial gastroenteritis in the developed world. We have investigated the importance of a homologue of the periplasmic HtrA protease in C. jejuni stress tolerance. A C. jejuni htrA mutant was constructed and compared to the parental strain, and we found that growth of the mutant was severely impaired both at 44 degrees C and in the presence of the tRNA...
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