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Article

Connexin 40, a target of transcription factor Tbx5, patterns wrist, digits, and sternum.

Molecular and cellular biology - 1 Jun 2005

Pizard Anne, Burgon Patrick G, Paul David L, Bruneau Benoit G, Seidman Christine E, Seidman J G

Abstract excerpt

Haploinsufficiency of T-box transcription factor 5 (TBX5) causes human Holt-Oram syndrome (HOS), a developmental disorder characterized by skeletal and heart malformations. Mice carrying a Tbx5 null allele (Tbx5(+/Delta)) have malformations in digits, wrists, and sternum joints, regions where Tbx5 is expressed. We demonstrate that mice deficient in connexin 40 (Cx40), a Tbx5-regulated gap junction component,...

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Source

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Identifiers

PMID: 15923624
DOI: 10.1128/MCB.25.12.5073-5083.2005
PMCID: PMC1140596

Genes

TBX5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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