Phenotypic and genotypic switch in Philadelphia-positive, BCR-positive blast crisis of chronic myeloid leukemia.

doi:10.1111/j.1600-0609.1992.tb01583.x

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Article

Phenotypic and genotypic switch in Philadelphia-positive, BCR-positive blast crisis of chronic myeloid leukemia.

European journal of haematology - 1 Apr 1992

Callea V, Morabito F, Francia di Celle P, Ronco F, Carbone A, Nobile F, Foa R

Abstract excerpt

We report a case of Ph1-positive, bcr-positive chronic myeloid leukemia blast crisis (CML-BC) which at presentation showed a mixed myeloid/B-lymphoid immunophenotype along with TdT positivity and, at the molecular level, an oligoclonal rearrangement of the immunoglobulin heavy chain (IgH) gene re...

Topics

Adult
Antigens, CD
Biomarkers, Tumor
Blotting, Northern
DNA
Gene Rearrangement
Genotype
Humans
Immunoglobulin Heavy Chains
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Male
Phenotype
Protein-Tyrosine Kinases
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-bcr
Recurrence

Source

Open in PubMed

Identifiers

PMID: 1592097
DOI: 10.1111/j.1600-0609.1992.tb01583.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1592097-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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