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Article

A Life-Long Search for the Molecular Pathways of Steroid Hormone Action

24 May 2005

Abstract excerpt

The O'Malley laboratory first showed that estrogen and progesterone act in the nucleus to stimulate synthesis of specific mRNAs (ovalbumin and avidin), coding for their respective inducible proteins. The overall molecular pathway of steroid-receptor-DNA-mRNA-protein-function was then established and provided a coherent foundation for future studies of the impact of estrogen and progesterone receptors on endocrine...

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PMID: 15914709
DOI: 10.1210/me.2004-0480

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