Article
Identification of mildly oxidized low-density lipoprotein (electronegative LDL) and its auto-antibodies IgG in children and adolescents hypercholesterolemic offsprings.
Atherosclerosis - 1 Jan 2006
Barros Marcos Roberto Andrade Costa, Bertolami Marcelo Chiara, Abdalla Dulcinéia Saes Parra, Ferreira Waldinai Pereira
Abstract excerpt
BACKGROUND: Oxidative modification of low-density lipoproteins (LDL) is an essential step in atherogenesis, generating minimally oxidized LDL, also called electronegative LDL [LDL(-)], which has chemotactic, cytotoxic and immunogenic properties. METHODS AND RESULTS: Serum LDL(-) and anti-LDL(-) auto-antibodies (IgG) were evaluated in 28 children and adolescents with familial hypercholesterolemia (FH) antecedents,...
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