BRCA1-2 mutations in breast cancer: identification of nine new variants of BRCA1-2 genes in a population from central Western Spain.

doi:10.1016/j.canlet.2005.03.006

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Article

BRCA1-2 mutations in breast cancer: identification of nine new variants of BRCA1-2 genes in a population from central Western Spain.

Cancer letters - 20 Feb 2006

Salazar Raquel, Cruz-Hernandez Juan Jesús, Sanchez-Valdivieso Enrique, Rodriguez César A, Gomez-Bernal Amalia, Barco Elviradel, Fonseca Emilio, Portugal Teresa, Gonzalez-Sarmiento Rogelio

Abstract excerpt

We carried out a mutational analysis of BRCA1 and BRCA2 genes in 103 individuals from a population in Western Central Spain and we identified nine new variants: two truncating mutations in BRCA2 [2604C>A (Y792X), 8873del4], three missense mutations in BRCA2 [677A>G (H150R), 958G>A (D224N) and 3398A>G (K1057R], and four silent mutations, two in BRCA1 [1115T>G (R332R) and IVS24+36 C>G], and two in BRCA2 [2583T>A...

Topics

Breast Neoplasms
Female
Genes, BRCA1
Genes, BRCA2
Humans
Mutation

Source

Open in PubMed

Identifiers

PMID: 15876480
DOI: 10.1016/j.canlet.2005.03.006

Genes

BRCA1
BRCA2

Variants

Provenance

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