Article
A new polymorphism of thyroxin-binding globulin in three African groups (Mali) with endemic nodular goitre.
Human genetics - 1 May 1992
Constans J, Ribouchon M T, Gouaillard C, Chaventré A, Clayton J
Abstract excerpt
The thyroxin-binding globulin (TBG) polymorphism was investigated in three African groups: two belonged to the Bwa villages of Mali, and the third was a Dogon group living in the same area. The Bwa groups were characterized by the occurrence of nodular goitres, whereas the Dogon population did not show similar pathological symptoms. Females were more affected by goitre than males in the affected villages. The TBG...
Topics
- Alleles
- Female
- Gene Frequency
- Goiter, Endemic
- Goiter, Nodular
- Humans
- Immunoblotting
- Isoelectric Focusing
- Male
- Mali
- Pedigree
- Polymorphism, Genetic