Article
Developmental dyslexia--recurrence risk estimates from a german bi-center study using the single proband sib pair design.
Human heredity - 1 Jan 2005
Ziegler Andreas, König Inke R, Deimel Wolfgang, Plume Ellen, Nöthen Markus M, Propping Peter, Kleensang André, Müller-Myhsok Bertram, Warnke Andreas, Remschmidt Helmut, Schulte-Körne Gerd
Abstract excerpt
OBJECTIVE: Several studies have demonstrated a genetic component for dyslexia. However, both segregation and linkage analyses show contradictory results pointing at the necessity of an optimal ascertainment scheme for molecular genetic studies. Previously, we have argued that the single proband sib pair design (SPSP) would be optimal. The aims of this paper therefore are to demonstrate the practicability of the...
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