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Article

Hemoglobin C modulates the surface topography of Plasmodium falciparum-infected erythrocytes.

Journal of structural biology - 1 May 2005

Arie Takayuki, Fairhurst Rick M, Brittain Nathaniel J, Wellems Thomas E, Dvorak James A

Abstract excerpt

There is a well-established clinical association between hemoglobin genotype and innate protection against Plasmodium falciparum malaria. In contrast to normal hemoglobin A, mutant hemoglobin C is associated with substantial reductions in the risk of severe malaria in both heterozygous AC and homozygous CC individuals. Irrespective of hemoglobin genotype, parasites may induce knob-like projections on the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 15866739
DOI: 10.1016/j.jsb.2005.02.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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