Article
[The role of nucleotide context in the induction of mutations in human mitochondrial DNA genes].
Genetika - 1 Mar 2005
Malyarchuk B A
Abstract excerpt
Based on the mutations distribution patterns in the mitochondrial DNA (mtDNA) genes, context analysis of the regions, including mutable positions characterized by the appearance of more than two parallel mutations, was performed. It was demonstrated that the mechanism of dislocation mutagenesis, leading to the appearance of mismatches within the frameshift regions of either primer or template mtDNA chains during...
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