Article
LET and ion-species dependence for mutation induction and mutation spectrum on hprt locus in normal human fibroblasts.
Uchu Seibutsu Kagaku - 1 Nov 2004
Tsuruoka Chizuru, Suzuki Masao, Fujitaka Kazunobu
Abstract excerpt
We have been studying LET and ion species dependence of RBE in mutation frequency and mutation spectrum of deletion pattern of exons in hprt locus. Normal human skin fibroblasts were irradiated with heavy-ion beams, such as carbon- (290 MeV/u and 135 MeV/u), neon- (230 MeV/u and 400 MeV/u), silicon- (490 MeV/u) and iron- (500 MeV/u) ion beams, generated by Heavy Ion Medical Accelerator in Chiba (HIMAC) at...
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