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Article

Mutation in the Na+ channel subunit SCN1B produces paradoxical changes in peripheral nerve excitability.

Brain : a journal of neurology - 1 Aug 2005

Kiernan Matthew C, Krishnan Arun V, Lin Cindy S-Y, Burke David, Berkovic Samuel F

Abstract excerpt

To determine the effect of an established mutation of the beta1 subunit of Na(+) channels on nerve excitability, studies were undertaken in patients diagnosed with generalized epilepsy with febrile seizures plus (GEFS+). Multiple nerve excitability measurements were used to investigate the membrane properties of sensory and motor axons in five patients (aged 18-55 years) who were currently experiencing no...

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Source

Identifiers

PMID: 15857929
DOI: 10.1093/brain/awh520

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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