Approaches to determine clinical significance of genetic variants.

doi:10.1016/j.mrfmmm.2005.01.009

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Article

Approaches to determine clinical significance of genetic variants.

Mutation research - 3 Jun 2005

MacAuley Alasdair, Ladiges Warren C

Abstract excerpt

The clinical significance of genetic variants (single nucleotide polymorphisms, SNPs) has implications for risk assessment and also for predicting the outcome of a disease process, especially in response to intervention. Approaches to determine the clinical significance of genetic polymorphisms are now beginning to be developed. The technology tools and procedures currently available have significant potential in...

Topics

Algorithms
Animals
DNA Repair
Humans
Mice
Models, Animal
Mutagenicity Tests
Polymorphism, Single Nucleotide

Source

Open in PubMed

Identifiers

PMID: 15829249
DOI: 10.1016/j.mrfmmm.2005.01.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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