Article
Lack of association between endometriosis and the CYP17 MspA1 polymorphism in UK and Japanese populations.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology - 1 Feb 2005
Asghar Tasneem, Yoshida Shigeki, Nakago Satoshi, Morizane Mayumi, Ohara Norita, Motoyama Satoru, Kennedy Stephen, Barlow David, Maruo Takeshi
Abstract excerpt
Endometriosis is a complex trait, which means that multiple susceptibility genes interact with one another and the environment to produce the phenotype. One of the genes previously implicated in the disease is CYP17; this encodes the enzyme P450c17alpha, which plays a vital role in steroid biosynthesis in the ovary. The presence of a single nucleotide polymorphism (T-->C) in the 5'-promoter region of the gene...
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