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Article

Progress in epidermolysis bullosa: the phenotypic spectrum of plectin mutations.

Experimental dermatology - 1 Apr 2005

Pfendner E, Rouan F, Uitto J

Abstract excerpt

Plectin, a large multidomain adhesive protein with versatile binding functions, is expressed in a number of tissues and cell types. In the skin, plectin is a critical component of hemidesmosomes, interacting with keratin intermediate filaments and beta4 integrin. Mutations in the plectin gene (PLEC1) result in fragility of skin, demonstrating blister formation at the level of hemidesmosomes. These blistering...

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Identifiers

PMID: 15810881
DOI: 10.1111/j.0906-6705.2005.00324.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Progress in epidermolysis bullosa: the phenotypic spectrum of plectin mutations.PMID 15810881Read ↗

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