Article
Role of endothelin axis in progression to aggressive phenotype of prostate adenocarcinoma.
The Prostate - 15 Sept 2005
Godara Geeta, Cannon Grant W, Cannon Glenn M, Bies Robert R, Nelson Joel B, Pflug Beth R
Abstract excerpt
BACKGROUND: Mitogenic and anti-apoptotic actions of endothelin-1 (ET-1) are mediated through endothelin A (ET(A)) receptors. We investigated endothelin receptor expression in increasingly aggressive phenotype and in vivo effects of combination therapy using ET(A) antagonist with paclitaxel. METHODS: Dunning prostate cancer cells ranged in aggressiveness from non-tumorigenic G, to tumorigenic, non-metastatic AT-1,...
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