Article
Widespread parallel evolution in sticklebacks by repeated fixation of Ectodysplasin alleles.
Science (New York, N.Y.) - 25 Mar 2005
Colosimo Pamela F, Hosemann Kim E, Balabhadra Sarita, Villarreal Guadalupe, Dickson Mark, Grimwood Jane, Schmutz Jeremy, Myers Richard M, Schluter Dolph, Kingsley David M
Abstract excerpt
Major phenotypic changes evolve in parallel in nature by molecular mechanisms that are largely unknown. Here, we use positional cloning methods to identify the major chromosome locus controlling armor plate patterning in wild threespine sticklebacks. Mapping, sequencing, and transgenic studies show that the Ectodysplasin (EDA) signaling pathway plays a key role in evolutionary change in natural populations and...
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