Article
Molecular basis for dissimilar nuclear trafficking of the actin-bundling protein isoforms T- and L-plastin.
Traffic (Copenhagen, Denmark) - 1 Apr 2005
Delanote Veerle, Van Impe Katrien, De Corte Veerle, Bruyneel Erik, Vetter Guillaume, Boucherie Ciska, Mareel Marc, Vandekerckhove Joël, Friederich Evelyne, Gettemans Jan
Abstract excerpt
T- and L-plastin are highly similar actin-bundling proteins implicated in the regulation of cell morphology, lamellipodium protrusion, bacterial invasion and tumor progression. We show that T-plastin localizes predominantly to the cytoplasm, whereas L-plastin distributes between nucleus and cytoplasm in HeLa or Cos cells. T-plastin shows nuclear accumulation upon incubation of cells with the CRM1 antagonist...
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