Article
Fibromodulin, an extracellular matrix protein: characterization of its unique gene and protein expression in B-cell chronic lymphocytic leukemia and mantle cell lymphoma.
Blood - 15 Jun 2005
Mikaelsson Eva, Danesh-Manesh Amir Hossein, Lüppert Alfred, Jeddi-Tehrani Mahmood, Rezvany Mohammad-Reza, Sharifian Ramazan Ali, Safaie Reza, Roohi Azam, Osterborg Anders, Shokri Fazel, Mellstedt Håkan, Rabbani Hodjattallah
Abstract excerpt
Fibromodulin is an extracellular matrix protein normally produced by collagen-rich tissues; the fibromodulin gene has been found to be the most overexpressed gene in B-cell chronic lymphocytic leukemia. In this study, fibromodulin was expressed at the gene level (reverse transcription-polymerase chain reaction [RT-PCR]) in all patients with B-CLL (n = 75) and in most (5 of 7) patients with mantle cell lymphoma...
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