Article
CCR5 chemokine receptor gene evolution in New World monkeys (Platyrrhini, Primates): implication on resistance to lentiviruses.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Apr 2005
Ribeiro Ieda P, Schrago Carlos G, Soares Esmeralda A, Pissinatti Alcides, Seuanez Hector N, Russo Claudia A M, Tanuri Amilcar, Soares Marcelo A
Abstract excerpt
The CC chemokine receptor 5 (CCR5) gene of primates encodes a transmembrane protein involved in cellular signaling of some cell types of the immune system. Numerous studies have shown that this peptide is used by lentiviruses in conjunction with the CD4 receptor to mediate binding and entry in target cells of human and non-human primates. New World monkeys (NWM), differently from their African counterparts, have...
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