Article
Colonization and inflammation deficiencies in Mongolian gerbils infected by Helicobacter pylori chemotaxis mutants.
Infection and immunity - 1 Mar 2005
McGee David J, Langford Melanie L, Watson Emily L, Carter J Elliot, Chen Yu-Ting, Ottemann Karen M
Abstract excerpt
Helicobacter pylori causes disease in the human stomach and in mouse and gerbil stomach models. Previous results have shown that motility is critical for H. pylori to colonize mice, gerbils, and other animal models. The role of chemotaxis, however, in colonization and disease is less well understood. Two genes in the H. pylori chemotaxis pathway, cheY and tlpB, which encode the chemotaxis response regulator and a...
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