Article
SNP haplotypes in the angiotensin I-converting enzyme (ACE) gene: analysis of Nigerian family data using gamete competition models.
Annals of human genetics - 1 Mar 2005
McKenzie C A, Sinsheimer J S, Adeyemo A A, Cox R D, Southam L, Hugill A, Bouzekri N, Lathrop M, Forrester T E, Cooper R S, Ward R
Abstract excerpt
Gamete competition models were used to explore the relationships between 13 ACE gene polymorphisms and plasma ACE concentration in a set of Nigerian families. Several markers in the 5' and 3' regions of the gene were significantly associated with ACE concentration (P < 10(-4)). Multi-locus genotypes comprising different combinations of markers from the 5' UTR and the 3' region of the gene were also analysed; in...
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