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An Endogenous Nuclease in Hamster, Mouse, and Human Spermatozoa Cleaves DNA into Loop‐Sized Fragments

4 Mar 2005

Abstract excerpt

Recent work from our laboratory provided evidence for the existence of a nuclease in hamster spermatozoa. This endogenous nuclease cleaves sperm chromatin at the bases of DNA loop domains into large fragments with an average size of roughly 50 kb. Here, we demonstrate that this sperm nuclease is present in the sperm nucleus and that it is activated by the presence of both calcium and magnesium much more...

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PMID: 15713834
DOI: 10.1002/j.1939-4640.2005.tb01095.x

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