Article
Prenatal diagnosis of minute supernumerary marker chromosomes.
Gynecologic and obstetric investigation - 1 Jan 2005
Cotter Philip D, Drexler Kathryn, Corley Amy L, Covert Susan M, Moland Jessica S, Govberg Inna J, Norton Mary E
Abstract excerpt
The identification of supernumerary marker chromosomes (SMC) at prenatal diagnosis is problematic, particularly for the prediction of phenotype. The assessment of phenotypic risk is based on the size, morphology and origin of the SMC. Fluorescence in situ hybridization (FISH) characterization and family studies are also employed to aid in determining the significance of a prenatally ascertained SMC. Generally,...
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