Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Germline hepatocyte nuclear factor 1α and 1β mutations in renal cell carcinomas

13 Jan 2005

Abstract excerpt

Mutations in one copy of the hepatocyte nuclear factors (HNF) 1alpha and 1beta homeodomain containing transcription factors predispose the carrier to maturity-onset diabetes of the young (MODY) types 3 and 5, respectively. Moreover, previous identification of biallelic inactivation of HNF1alpha in hepatocellular adenoma identified its tumor suppressor function in hepatocarcinogenesis. The seminal observation of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Genetic and Kidney Cyst Diseases
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15649945
DOI: 10.1093/hmg/ddi057

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Germline hepatocyte nuclear factor 1α and 1β mutations in renal cell carcinomasPMID 15649945Read ↗

Mutation of hepatocyte nuclear factor-1beta inhibits Pkhd1 gene expression and produces renal cysts in mice.Semantic proximity Read ↗

Mutations in hepatocyte nuclear factor-1β and their related phenotypesSemantic proximity Read ↗

HNF1B-associated renal and extra-renal disease-an expanding clinical spectrum.Semantic proximity Read ↗

Mutations in the human genes encoding the transcription factors of the hepatocyte nuclear factor (HNF)1 and HNF4 families: functional and pathological consequences.Semantic proximity Read ↗

HNF1B-associated clinical phenotypes: the kidney and beyond.Semantic proximity Read ↗

The Landscape of HNF1B Deficiency: A Syndrome Not Yet Fully ExploredSemantic proximity Read ↗

Solitary functioning kidney and diverse genital tract malformations associated with hepatocyte nuclear factor-1beta mutations.Semantic proximity Read ↗

Hepatocyte nuclear factor-1 gene deletions--a common cause of renal diseaseSemantic proximity Read ↗

Renal cysts and diabetes syndrome resulting from mutations in hepatocyte nuclear factor-1Semantic proximity Read ↗

Severe pancreas hypoplasia and multicystic renal dysplasia in two human fetuses carrying novel HNF1β/MODY5 mutationsSemantic proximity Read ↗

Variable phenotype in HNF1B mutations: extrarenal manifestations distinguish affected individuals from the population with congenital anomalies of the kidney and urinary tractSemantic proximity Read ↗

Hepatocyte nuclear factor-1beta(HNF-1beta) in human urogenital organs: its expression and role in embryogenesis and tumorigenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.