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Article

HIV-reverse transcriptase inhibition: inclusion of ligand-induced fit by cross-docking studies.

Journal of medicinal chemistry - 13 Jan 2005

Ragno Rino, Frasca Simona, Manetti Fabrizio, Brizzi Antonella, Massa Silvio

Abstract excerpt

Nonnucleoside reverse transcriptase inhibitors (NNRTIs) have, in addition to the nucleoside reverse transcriptase inhibitors (NRTIs) and protease inhibitors (PIs), a definitive role in the treatment of HIV-1 infections. Since the appearance of HEPT and TIBO, more than 30 structurally different classes of compounds have been reported as NNRTIs, which are specific inhibitors of HIV-1 replication, targeting the...

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Identifiers

PMID: 15634014
DOI: 10.1021/jm0493921

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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