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Article

Posttranscriptional down-regulation of small ribosomal subunit proteins correlates with reduction of 18S rRNA in RPS19 deficiency.

FEBS letters - 18 Jun 2009

Badhai Jitendra, Fröjmark Anne-Sophie, Razzaghian Hamid Reza, Davey Edward, Schuster Jens, Dahl Niklas

Abstract excerpt

Ribosomal protein S19 (RPS19) is mutated in patients with Diamond-Blackfan anemia (DBA). We hypothesized that decreased levels of RPS19 lead to a coordinated down-regulation of other ribosomal (r-)proteins at the subunit level. We show that small interfering RNA (siRNA) knock-down of RPS19 results in a relative decrease of small subunit (SSU) r-proteins (S20, S21 and S24) when compared to large subunit (LSU)...

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Share to Anemia, Diamond-Blackfan
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Ribosomal Proteins

Share to RNA Processing, Post-Transcriptional

Share to RNA, Ribosomal, 18S

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Share to RNA, Small Interfering

Source

Open in PubMed Open full text

Identifiers

PMID: 19454283
DOI: 10.1016/j.febslet.2009.05.023
PMCID: PMC2737615

Genes

RPS19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Posttranscriptional down-regulation of small ribosomal subunit proteins correlates with reduction of 18S rRNA in RPS19 deficiency.PMID 19454283Read ↗

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