Article
Novel germline mutations in breast cancer susceptibility genes BRCA1, BRCA2 and p53 gene in breast cancer patients from India.
Breast cancer research and treatment - 1 Nov 2004
Hedau Suresh, Jain Neeraj, Husain Syed A, Mandal Ashish K, Ray Gibanananda, Shahid M, Kant Ravi, Gupta Vishal, Shukla Nootan K, Deo Suryanarayan S V, Das Bhudev C
Abstract excerpt
Mutations in breast cancer susceptibility genes, BRCA1 and BRCA2 account for more than 80% of hereditary breast and ovarian cancers. p53 tumor suppressor gene that controls cellular growth and differentiation is also known to be mutated in more than 50% of human cancers including breast cancer. We have carried out a study on BRCA1 and BRCA2 along with p53 gene mutations in both sporadic as well as familial breast...
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