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Article

The role of phenylalanine hydroxylase in melanotic encapsulation of filarial worms in two species of mosquitoes.

Insect biochemistry and molecular biology - 1 Dec 2004

Infanger Li-Chun, Rocheleau Thomas A, Bartholomay Lyric C, Johnson Jody K, Fuchs Jeremy, Higgs Stephen, Chen Cheng-Chen, Christensen Bruce M

Abstract excerpt

Melanin formation has a significant influence on mosquito vector competence by limiting the development of metazoan parasites. Tyrosine, the rate-limiting substrate of melanin production, can be obtained exogenously or derived from phenylalanine by phenylalanine hydroxylase (PAH). The characteris...

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Source

Identifiers

PMID: 15544946
DOI: 10.1016/j.ibmb.2004.09.004

Genes

PAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15544946-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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