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Article

The role of phenylalanine hydroxylase in melanotic encapsulation of filarial worms in two species of mosquitoes.

Insect biochemistry and molecular biology - 1 Dec 2004

Infanger Li-Chun, Rocheleau Thomas A, Bartholomay Lyric C, Johnson Jody K, Fuchs Jeremy, Higgs Stephen, Chen Cheng-Chen, Christensen Bruce M

Abstract excerpt

Melanin formation has a significant influence on mosquito vector competence by limiting the development of metazoan parasites. Tyrosine, the rate-limiting substrate of melanin production, can be obtained exogenously or derived from phenylalanine by phenylalanine hydroxylase (PAH). The characteristics of this defense mechanism, such as temporal expression of constituent enzymes involved in the biosynthetic...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15544946
DOI: 10.1016/j.ibmb.2004.09.004

Genes

PAH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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