Article
Hormonal regulation of 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase in rat liver cytosol.
Biochemical pharmacology - 3 Mar 1992
Penning T M, Isaacson K, Lyttle C R
Abstract excerpt
In rat liver, dihydrodiol dehydrogenase and 3 alpha-hydroxysteroid dehydrogenase activities are catalyzed by the same protein. This study shows that estrogen and growth hormone can induce the enzyme in hypophysectomized rats. This implies that estrogen can exert an effect on hepatic steroid and carcinogen metabolism in the absence of the anterior pituitary.
Topics
- 3-Hydroxysteroid Dehydrogenases
- 3-alpha-Hydroxysteroid Dehydrogenase (B-Specific)
- Age Factors
- Animals
- Cytosol
- Enzyme Induction
- Estradiol
- Female
- Growth Hormone
- Hypophysectomy
- Liver
- Male