Article
Re-evaluation of reading frame-shift hypothesis in Duchenne and Becker muscular dystrophy.
Neurology India - 1 Sept 2003
Pandey G S, Kesari A, Mukherjee M, Mittal R D, Mittal B
Abstract excerpt
The reading frame hypothesis has been proposed to explain the molecular basis of two allelic forms of muscular dystrophies, Duchenne/Becker muscular dystrophy (D/BMD). To evaluate the hypothesis in Indian D/BMD patients, we analyzed deletion of dystrophin exons in 147 DMD and 19 BMD patients. Our studies showed deviation of more than 30% from the reading frame hypothesis in DMD patients (47/147). The present...
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