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Article

FVIII gene delivery by muscle electroporation corrects murine hemophilia A.

The journal of gene medicine - 1 Apr 2005

Long Yun Chau, Jaichandran S, Ho Liam Pock, Tien Sim Leng, Tan Soo Yong, Kon Oi Lian

Abstract excerpt

BACKGROUND: Hemophilia A treatment relies on costly factor VIII (FVIII) replacement that may transmit iatrogenic viral diseases. Viral vectors and cell implants are being developed as improvements. We investigated in vivo electroporation of naked DNA as a safe and simple method for correcting FVIII deficiency. METHODS: B-domain-deleted murine FVIII cDNA expression plasmids were constructed with CMV and elongation...

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Identifiers

PMID: 15521095
DOI: 10.1002/jgm.683

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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